Sodium thiocyanate → HCID 21569100, compound

HRID 1579840Notes

Reaction equation

HRID 1579840 reaction equation
[S-:1][C:2]#[N:3].[Na+].Cl[CH:6]([C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:20][CH3:21])[CH:16]=2)[CH:11]=1)[C:7]([OH:9])=[O:8]>C(O)C>[S:1]([CH:6]([C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:20][CH3:21])[CH:16]=2)[CH:11]=1)[C:7]([OH:9])=[O:8])[C:2]#[N:3]

Participants

4

Reactant 2

HCID 516871Sodium thiocyanateHCID 21569134HCID 21569134, compound

Product 1

HCID 21569100HCID 21569100, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 300 ml. of anhydrous ethanol and 0.15 moles of sodium thiocyanate is added 0.12 moles of α-chloro-6-methoxy-2-naphthylacetic acid and stirred for 15 hours. The reaction mixture is filtered and washed with absolute ethanol. The filtrate is evaporated to dryness, the residue is dissolved in 250 ml. of ether and washed several times with water. The ether is then dried and evaporated to dryness to obtain α-thiocyanato-6-methoxy-2-naphthylacetic acid.

Workup

  1. filtrationThe reaction mixture is filtered
  2. washwashed with absolute ethanol
  3. customThe filtrate is evaporated to dryness
  4. dissolutionthe residue is dissolved in 250 ml
  5. washof ether and washed several times with water
  6. dry with materialThe ether is then dried
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-9a762cff2bfb47e08ba0d2b9f7b4664a
Source dataset
uspto-grants-1976_01
Patent number
US03931269

Reaction notes

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