HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminobenzoic Acid → 1-(3-Carboxyphenyl)-2-phenyl-4,5,6,7-tetrahydroindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminobenzoic Acid | HCID 7419 | — |
| Reactant | 2-(2-Oxo-2-phenylethyl)cyclohexanone | HCID 10512899 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(3-Carboxyphenyl)-2-phenyl-4,5,6,7-tetrahydroindole | HCID 12270273 | — |
Reaction Steps
A solution of 10.8 g. (0.05 mole) of 2-phenacylcyclohexanone, 6.85 g. (0.05 mole) of m-aminobenzoic acid and 30 ml. of glacial acetic acid was heated under reflux for 6 hours, cooled and filtered. The filter cake was washed with water and recrystallized from ethanol to provide 5.7 g. (36%) of crystals, m.p. 191°-193°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931407 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-b1fcd584fbe64fe1b87ff6884de54069 |
| Source note | uspto-grants-1976_01 |