5-Aminosalicylic Acid → HCID 12270312, compound

Participants

Reaction Steps

A mixture of 20.0 g. (0.076 mole) of 2-phenacyl-1-tetralone, 11.6 g. (0.076 mole) of 5-aminosalicylic acid, and 70 ml. of glacial acetic acid was heated under reflux for 4 hours, cooled diluted with 10 ml. of water and filtered. The filter cake was washed with water and dried to provide 15.5 g. of solid, m.p. 215°-218°. Recrystallization from benzene-cyclohexane gave 6.5 g. (22%) of yellow crystals, m.p. 245°-247°.

Provenance & Evidence