Hydrochloric Acid → HCID 12270299, compound

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Reaction Steps

A mixture of 6.18 g. (0.015 mole) of 2-(4-bromophenyl)-1-(3-carboxy-4-hydroxyphenyl)-4,5,6,7-tetrahydroindole, 1.6 g. (0.018 mole) of cuprous cyanide, and 10 ml. of dimethyl formamide was heated under reflux for 6 hours, poured into a solution of 3 g. of sodium cyanide and 10 ml. of water, and after 5 minutes diluted with 46 ml. of water. The solution was acidified to pH 1-2 with hydrochloric acid and the solid which separated was collected. Recrystallization from acetic acid gave 1.21 g. (23%) of crystals, m.p. 242°-244°.

Provenance & Evidence