反应详情

Hydrogen chloride gas was bubbled through a stirred, boiling mixture of 30.0 g. (0.08 mole) of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole and 790 ml. of methanol for 1 hour. The mixture was stirred under reflux for 6 hours, cooled and filtered to provide 28.4 g. (91%) of solid. Recrystallization from acetonitrile gave colorless crystals, m.p. 164.5°-165.5°.

1. customHydrogen chloride gas was bubbled through a stirred
2. additionmixture of 30.0 g
3. temperatureunder reflux for 6 hours
4. temperaturecooled
5. filtrationfiltered
6. customto provide 28.4 g
7. customRecrystallization from acetonitrile
8. customgave colorless crystals, m.p. 164.5°-165.5°