5-Aminosalicylic Acid → HCID 12270290, compound

Participants

Reaction Steps

A mixture of 24.6 g. (0.1 mole) of 2-(m-methoxyphenacyl)cyclohexanone, 15.3 g. (0.1 mole) of 5-aminosalicylic acid, and 65 ml. of glacial acetic acid was heated for 2 hours under reflux under nitrogen and cooled. The solid which separated was collected, washed with acetic acid and water, dried and recystallized from acetic acid to provide 23.4 g. (65%) of crystals, m.p. 175°-177°.

Provenance & Evidence