2-(2-Oxo-2-phenylethyl)cyclohexanone → HCID 12270287, compound

HRID 1579891Notes

Reaction equation

HRID 1579891 reaction equation
[CH2:1]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.[NH2:17][C:18]1[CH:26]=[C:22]([C:23]([OH:25])=[O:24])[C:21]([OH:27])=[C:20]([Cl:28])[CH:19]=1>C(O)(=O)C>[C:23]([C:22]1[CH:26]=[C:18]([N:17]2[C:11]3[CH2:12][CH2:13][CH2:14][CH2:15][C:10]=3[CH:1]=[C:2]2[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:19]=[C:20]([Cl:28])[C:21]=1[OH:27])([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 105128992-(2-Oxo-2-phenylethyl)cyclohexanoneHCID 20327552HCID 20327552, compound

Product 1

HCID 12270287HCID 12270287, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

a mixture of 10.3 g. (0.047 mole) of 2-phenacylcyclohexanone, 8.8 g. (0.047 mole) of 5-amino-3-chlorosalicylic acid, and 45 ml. of glacial acetic acid was heated under reflux for 1 hour, cooled and filtered. The collected solid was recrystallized from acetonitrile to provide 13.3 g. (77%) of crystals, m.p. 223°-225°.

Workup

  1. additiona mixture of 10.3 g
  2. temperatureunder reflux for 1 hour
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe collected solid was recrystallized from acetonitrile
  6. customto provide 13.3 g

Sources & evidence

ORD record
ord-1abc9564c0c643f28b92a059048891ea
Source dataset
uspto-grants-1976_01
Patent number
US03931407

Reaction notes

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