5-Aminosalicylic Acid → HCID 12270314, compound

Participants

Reaction Steps

A mixture of 5.8 g. (0.02 mole) of 6-methoxy-1-phenacyl-2-tetralone, 3.02 g. (0.02 mole) of 5-aminosalicylic acid, and 20 ml. of glacial acetic acid was heated under reflux for 1 hour, cooled, and filtered. The collected solid was washed with acetic acid and petroleum ether and recrystallized from acetonitrile to provide 5.3 g (67%) of pale yellow crystals, m.p. 233°-234°.

Provenance & Evidence