5-Aminosalicylic Acid → HCID 12270301, compound

Participants

Reaction Steps

A mixture of 2.22 g. (0.01 mole) of 2-(2-thienoylmethyl)cyclohexanone, (1.53 g. (0.01 mole) of 5-aminosalicylic acid, and 25 ml. of ethanol was heated uder reflux under nitrogen for 4 hours and filtered. The filtrate was concentrated to an oil which solidified when triturated with petroleum ether. Recrystallization from acetonitrile gave 1.0 g. (29%) of yellow crystals, m.p. 211°-213°.

Provenance & Evidence