HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1579958Generated: November 3, 2026
Dichlorodimethylsilane → 7-Aminodeacetoxycephalosporanic acid
https://huagongshe.com/reaction/1579958
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichlorodimethylsilane | HCID 6398 | — |
| Reactant | Dicyclohexylamine | HCID 7582 | — |
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 7-Phenoxyacetamido-3-methyl-3-cephem-4-carboxylic acid | HCID 15573400 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Aminodeacetoxycephalosporanic acid | HCID 33498 | — |
Reaction Steps
7-(Phenoxyacetamido)-3-methyl-3-cephem-4-carboxylic acid (11.38 mmoles) is dissolved in 80 ml of methylene chloride. Dicyclohexylamine or diisopropylamine (13 mmoles) is added with stirring and 1.75 ml of dichlorodimethylsilane is added. After stirring for 30 minutes, the mixture is cooled to -45° C and an additional 27.77 mmoles of the same amine as used above is added followed by 3 g of finely powdered PCl5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03932392 |
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| Source dataset | uspto-grants-1976_01 |
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| ORD ID | ord-7bfcc8b0f6f04df4b0d800fcb15d045b |
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| Source note | uspto-grants-1976_01 |
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