HCID 54233514, compound → HCID 73186002, compound

HRID 1579978Notes

Reaction equation

HRID 1579978 reaction equation
C(C(C(OCC)=O)=NC=C(N1CCOCC1)C1C=CC=CC=1)#N.[C:24]([C:26]([C:43]([O:45][CH3:46])=[O:44])=[N:27][C:28]([CH3:42])=[C:29]([N:36]1CCOCC1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)#[N:25]>>[C:24]([C:26]([C:43]([O:45][CH3:46])=[O:44])=[N:27][C:28]([CH3:42])=[C:29]([NH2:36])[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)#[N:25]

Participants

3

Reactant 2

HCID 54233514HCID 54233514, compoundHCID 86732917HCID 86732917, compound

Product 1

HCID 73186002HCID 73186002, compound

Procedure

One operates as in Example 12, but the 1-cyano-1-ethoxycarbonyl-4-morpholino-4-phenyl-2-aza-1,3-butadiene is replaced by 1-cyano-1-methoxycarbonyl-3-methyl-4-morpholino-4-phenyl-2-aza-1,3-butadiene and the reaction is effected at -30°C. 4.1 parts of 1-cyano-1-methoxycarbonyl-3-methyl-4-amino--4-phenyl-2-aza-1,3-butadiene are obtained after a reaction time of 3 days. After recrystallisation from methanol the product melts at 145°C.

Workup

  1. customis effected at -30°C

Sources & evidence

ORD record
ord-f5ea77c67ddd44c683fc2b9d505a2b33
Source dataset
uspto-grants-1976_01
Patent number
US03932404

Reaction notes

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