Ammonia → HCID 135823917, compound

HRID 1579995Notes

Reaction equation

HRID 1579995 reaction equation
Cl[C:2]1[N:11]([CH2:12][C:13]([O:15]CC)=O)[CH:10]([CH3:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:19])[N:3]=1.[NH3:20]>C(O)C>[CH3:18][CH:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:19])[N:3]=[C:2]2[NH:20][C:13](=[O:15])[CH2:12][N:11]12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20454788HCID 20454788, compound

Product 1

HCID 135823917HCID 135823917, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 4.3 g (15.4 mmole) of 2-chloro-3-(carbethoxymethyl)-4,5-dimethyl-3,4-dihydroquinazoline in 50 ml of absolute ethanol was added a solution of 2.0 g (120 mmole) of ammonia in 25 ml of absolute ethanol, the system was stoppered and immersed in an oil bath (100°). After 16 hrs. of heating, the solution was cooled, the solvent removed in vacuo and the residue crystallized from 1N hydrochloride acid affording 2.29 g (59% yield) of yellow crystals mp 235°-40°.

Workup

  1. customimmersed in an oil bath
  2. custom(100°)
  3. temperatureof heating
  4. temperaturethe solution was cooled
  5. customthe solvent removed in vacuo
  6. customthe residue crystallized from 1N hydrochloride acid

Sources & evidence

ORD record
ord-a2c51d095e31475a8173b5ac952231bf
Source dataset
uspto-grants-1976_01
Patent number
US03932407

Reaction notes

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