Water → HCID 68137829, compound

HRID 1580036Notes

Reaction equation

HRID 1580036 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].Cl[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[CH2:19][CH2:18]1.O>>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([N:20]2[CH2:19][CH2:18][N:17]([CH2:16][CH2:15][CH2:14][O:1][C:2]3[CH:11]=[CH:10][CH:9]=[C:8]4[C:3]=3[CH2:4][CH2:5][CH2:6][C:7]4=[O:12])[CH2:22][CH2:21]2)=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 962WaterHCID 1199215-Hydroxy-1-tetraloneHCID 2336721-(4-chlorophenyl)-4-(3-chloropropyl)piperazine

Product 1

HCID 68137829HCID 68137829, compoundYield 70%

Procedure

from 5-hydroxy-1-oxotetraline and 1-(3-chloropropyl)-4-(4-chlorophenyl)-piperazine; yield 70.0% of theory; the hydrochloride, after recrystallization from 96% ethanol and drying in a vacuum desiccator, still contained 0.55 mol water; m.p. 189°-191°C;

Workup

  1. customthe hydrochloride, after recrystallization from 96% ethanol

Sources & evidence

ORD record
ord-051d0f03ab144ac98d1da09c0c2646f7
Source dataset
uspto-grants-1976_01
Patent number
US03932411

Reaction notes

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