5-Hydroxy-1-tetralone → HCID 21564757, compound

HRID 1580042Notes

Reaction equation

HRID 1580042 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].Cl[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[Br:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][N:20]2[CH2:21][CH2:22][N:17]([CH2:16][CH2:15][CH2:14][O:1][C:2]3[CH:11]=[CH:10][CH:9]=[C:8]4[C:3]=3[CH2:4][CH2:5][CH2:6][C:7]4=[O:12])[CH2:18][CH2:19]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 1199215-Hydroxy-1-tetraloneHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 21564753HCID 21564753, compound

Product 1

HCID 21564757HCID 21564757, compoundYield 50%

Procedure

From 5-hydroxy-1-oxotetraline and 1-(3-chloropropyl)-4-(4-bromobenzyl)-piperazine; yield 50% of theory; m.p. of the dihydrochloride (recrystallized from 1N hydrochloric acid) 256°-259°C (decomposed);

Sources & evidence

ORD record
ord-11604e7038fb413c9d149d2c088cde96
Source dataset
uspto-grants-1976_01
Patent number
US03932411

Reaction notes

Loading…