5-Hydroxy-1-tetralone → HCID 21564740, compound

HRID 1580043Notes

Reaction equation

HRID 1580043 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].Cl[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])[CH2:19][CH2:18]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][N:20]1[CH2:19][CH2:18][N:17]([CH2:16][CH2:15][CH2:14][O:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH2:4][CH2:5][CH2:6][C:7]3=[O:12])[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 1199215-Hydroxy-1-tetraloneHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 23330447HCID 23330447, compound

Product 1

HCID 21564740HCID 21564740, compoundYield 57.1%

Procedure

from 5-hydroxy-1-oxotetraline and 1-(3-chloropropyl)-4-(2-methoxybenzyl)-piperazine; yield 57.1% of theory; m.p. of the dihydrochloride (recrystallized from 1N hydrochloric acid) 241°-243°C;

Sources & evidence

ORD record
ord-a539c2fa050f449394651926c0ccdf04
Source dataset
uspto-grants-1976_01
Patent number
US03932411

Reaction notes

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