Water → HCID 21564746, compound

HRID 1580045Notes

Reaction equation

HRID 1580045 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].Cl[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[O:29][CH2:30][CH3:31])[CH2:19][CH2:18]1.O>>[CH2:30]([O:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:20]1[CH2:21][CH2:22][N:17]([CH2:16][CH2:15][CH2:14][O:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH2:4][CH2:5][CH2:6][C:7]3=[O:12])[CH2:18][CH2:19]1)[CH3:31]

Participants

4

Reactant 3

HCID 962WaterHCID 1199215-Hydroxy-1-tetraloneHCID 20138239HCID 20138239, compound

Product 1

HCID 21564746HCID 21564746, compoundYield 86%

Procedure

from 5-hydroxy-1-oxotetraline and 1-(3-chloropropyl)-4-(2-ethoxyphenyl)-piperazine; yield 86% of theory; the hydrochloride, after recrystallization from water, contained, after drying, 0.406 mol water; m.p. 196°-197°C.

Workup

  1. customthe hydrochloride, after recrystallization from water
  2. customafter drying

Sources & evidence

ORD record
ord-27c287fa75ae47f0bbe710bb2cf9ae34
Source dataset
uspto-grants-1976_01
Patent number
US03932411

Reaction notes

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