反应详情

Methylisothiocyanate (1.46 g.) was added slowly to a solution of N-(4-picolyl)ethylenediamine (3.3 g.) in ethanol (25 ml.) The mixture was heated under reflux for 0.5 hours concentrated and extracted with isopropyl acetate to remove N-4-picolyl-N,N'-dimethylethane-1,2-bis thiourea (m.p. 173°-174°). The mother liquors were concentrated and the residue purified by column chromatography to afford the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 0.5 hours
3. concentrationconcentrated
4. extractionextracted with isopropyl acetate
5. customto remove N-4-picolyl-N,N'-dimethylethane-1,2-bis thiourea (m.p. 173°-174°)
6. concentrationThe mother liquors were concentrated
7. customthe residue purified by column chromatography