反应详情

A mixture of 9.86 (0.05 mole of 5-methyl-2-phenyl-4-imidazoleacetonitrile and 15 ml of concentrated sulfuric acid is stirred and warmed on a steam bath until solution is complete (about 25 minutes). The warm mixture is poured onto excess ice and basified with a slight excess of concentrated aqueous ammonia. Recrystallization from ethanol (95%)-water affords the product, 5-methyl-2-phenyl-4-imidazoleacetamide hydrate, m.p. 186°-188°C. The melting point can be changed to 202°-4°C by thoroughly grinding in an agate mortar. The product can also be made to melt over the range of about 186°-204°C by very slowly raising the oilbath temperature. Treatment with mineral acid, e.g., sulfuric or hydrobromic acid, affords the corresponding acid addition salt.

1. temperaturewarmed on a steam bath until solution
2. custom(about 25 minutes)
3. additionThe warm mixture is poured onto excess ice
4. customRecrystallization from ethanol (95%)-water