Potassium Iodide → 1-Butanone, 1-(4-fluorophenyl)-4-(1-(3-methoxyphenyl)-6-azabicyclo(3.2.1)oct-6-yl)-, hydrochloride, (+-)-

Participants

Reaction Steps

A mixture of 0.8 g of 1-(3-methoxyphenyl)-6-azabicyclo[ 3,2,1]octane, 0.81 g of 3-(4-fluorobenzoyl)propyl chloride, 0.8 g of potassium carbonate, 0.03 g of potassium iodide and 20 ml of toluene is refluxed for 48 hours. After cooling, the mixture is treated in the same manner as described in Example 11. 0.65 g of 1-(3-methoxyphenyl)-6-[3-(4-fluorobenzoyl)propyl]-6-azabicyclo[3,2,1]octane hydrochloride is obtained. M.p. 195° - 196°C(recrystallized from a mixture of ethanol and ether).

Provenance & Evidence