HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-(6-Azabicyclo[3.2.1]octan-1-yl)phenol--hydrogen bromide (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Oxalic acid--1-(3-methoxyphenyl)-6-azabicyclo[3.2.1]octane (1/1) | HCID 3045728 | — |
| Product | 3-(6-Azabicyclo[3.2.1]octan-1-yl)phenol--hydrogen bromide (1/1) | HCID 3045777 | — |
Reaction Steps
A mixture of 9 g of 1-(3-methoxyphenyl)-6-azabicyclo[ 3,2,1]octane oxalate and 90 ml of aqueous 48% hydrobromic acid is refluxed for 1.5 hours. After the reaction, the mixture is concentrated under reduced pressure. The residue thus obtained is recrystallized from a mixture of ethanol and ether. 7.7 g of 1-(3-hydroxyphenyl)-6-azabicyclo[3,2,1]octane hydrobromide are obtained. M.p. 239° - 242°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03932429 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-10a0f66228cb4a6dadc2720ce7f8e9d0 |
| Source note | uspto-grants-1976_01 |