HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-(7-Methyl-6-azabicyclo[3.2.1]octan-1-yl)phenol--hydrogen bromide (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 21564931 | HCID 21564931 | — |
| Product | 3-(7-Methyl-6-azabicyclo[3.2.1]octan-1-yl)phenol--hydrogen bromide (1/1) | HCID 3045732 | — |
Reaction Steps
A mixture of 5.22 g of 1-(3-methoxyphenyl)-7-methyl-6-azabicyclo[3,2,1]octane hydrochloride and 52 ml of 47 % aqueous hydrobromic acid is refluxed for one hour under heating. After cooling, the crystalline precipitate is collected by filtration. The precipitate is recrystallized from a mixture of methanol and ether. 5.48 g of 1-(3-hydroxyphenyl)-7-methyl-6-azabicyclo[3,2,1]octane hydrobromide are obtained. M.p. 282°-284°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03932429 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-b66b9264cdc44c39aad01eeca89c881b |
| Source note | uspto-grants-1976_01 |