1-(3-Methoxyphenyl)-6,7-dimethyl-6-azabicyclo[3.2.1]octane--hydrogen bromide (1/1) → HCID 3045735, compound

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Reaction Steps

A mixture of 3.1 g of 1-(3-methoxyphenyl)-6,7-dimethyl- 6-azabicyclo[3,2,1]octane hydrobromide and 30 ml of 48% aqueous hydrobromic acid is refluxed for 1.5 hours. After the reaction, the mixture is concentrated under reduced pressure. Aqueous ammonia is added to the residue, and the aqueous mixture is extracted with chloroform. The chloroform extract is washed with water, dried and then evaporated to remove solvent. The residue thus obtained is recrystallized from ethylacetate. 2.1 g of 1-(3-hydroxyphenyl)-6,7-dimethyl-6-azabicyclo[3,2,1]octane is obtained.

Provenance & Evidence