3-(4-Pyridyl)-2,3,3a,4,5,6-hexahydrobenzo[6,7]cyclohepta[1,2-c] pyrazole → HCID 178419887, compound

HRID 1580159Notes

Reaction equation

HRID 1580159 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[NH:11][N:10]=[C:9]3[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=4[CH2:14][CH2:15][CH2:16][CH:8]23)=[CH:3][CH:2]=1>[O-2].[O-2].[Mn+4].C1C=CC=CC=1>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[NH:11][N:10]=[C:9]3[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=4[CH2:14][CH2:15][CH2:16][C:8]=23)=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 215649633-(4-Pyridyl)-2,3,3a,4,5,6-hexahydrobenzo[6,7]cyclohepta[1,2-c] pyrazole

Product 1

HCID 178419887HCID 178419887, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 241BenzeneSolvent

Procedure

Into a flask eqipped with a magnetic stirring bar is charged 5.0 grams of 3-(4-pyridyl)-2,3,3a,4,5,6-hexahydrobenzo[6,7]cyclohepta[1,2-c] pyrazole, 25 grams of activated manganese dioxide and 150 ml of dry benzene. The mixture is stirred for about 12 hours at room temperature, after which the manganese salts are filtered off and the solvent removed in vacuo. The solid is crystallized from ethanol to give 3-(4-pyridyl)-2,4,5,6-tetrahydrobenzo[ 6,7]cyclohepta[1,2-c]pyrazole (m.p. 217°-219°C).

Workup

  1. customInto a flask eqipped with a magnetic stirring bar
  2. filtrationafter which the manganese salts are filtered off
  3. customthe solvent removed in vacuo
  4. customThe solid is crystallized from ethanol

Sources & evidence

ORD record
ord-46eddc267fac4966a2ddfacf8695e3f6
Source dataset
uspto-grants-1976_01
Patent number
US03932430

Reaction notes

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