Hydrochloric Acid → 2-amino-4-oxo-4H-1-benzopyran-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

-- A mixture of 6.6 g (0.1 mole) of malononitrile, 50 g of ice, 5 ml of 20% sodium hydroxide and 9.9 g (0.5 mole) of 2-acetoxy benzoyl chloride is stirred vigorously for 10 minutes. Second portions of malononitrile and 20% sodium hydroxide are added, the mixture is stirred another 10 minutes, then warmed to 40°C. With stirring, there is added 50% potassium hydroxide solution in 5 ml increments until the solution becomes clear. The solution is cooled, acidified with conc. HCl, and the solid filtered and washed with water and air dried, mp 315°-20°C.

Provenance & Evidence