Potassium Carbonate → HCID 18594687, compound

Participants

Reaction Steps

A solution of 2.26 g. of methyl 15(S)-acetoxy-9-oxoprostanoate (Example 52) in 300 ml. of absolute alcohol containing 790 mg. of potassium carbonate is stirred at ambient temperature for 72 hours then concentrated to near dryness under reduced pressure. The resulting mixture is extracted with ether. The combined extracts are washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate and taken to dryness to give 1.83 g. of an oil. Purification by silica gel chromatography affords the subject compound as an oil; λ max. 2.92 (hydroxyl group), 5.74 μ (carbonyl groups); [α]D25 -23°C. (0.2% in CHCl3).

Provenance & Evidence