Hydrochloric Acid → HCID 12251437, compound

Participants

Reaction Steps

A mixture of 4g. (0.016 M) of spiro(cyclohexane-1,2'-indan)-4-one ethylene ketal [10] (prepared in Example 20B) and 8 ml. of 2.5 N hydrochoric acid in 80 ml. of acetone is heated at reflux for about 4 hours. Most of the solvent is removed under vacuum and ether added. The organic layer is separated, washed with water and brine and evaporated to dryness. The residue is chromatographed on a 350 ml. column of silica gel with elution by methylene chloride. Those fractions similar by thin layer chromatography are combined to give spiro(cyclohexane-1,2'-indan)-4-one [11] as an amorphous gum.

Provenance & Evidence