HCID 21566278, compound → HCID 21566291, compound

HRID 1580288Notes

Reaction equation

HRID 1580288 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8](C)([C:14]([O-])=O)[C:9]([O:11]CC)=[O:10])[CH:5]=[CH:4][C:3]=1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1.FC1C=C(C(C)(C(O)=O)C(O)=O)C=CC=1C1C=CC(F)=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:14])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:18]1[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 21566278HCID 21566278, compoundHCID 21566295HCID 21566295, compound

Product 1

HCID 21566291HCID 21566291, compound

Procedure

By procedures similar to those described in Example 1, ethyl 2-(2,4'-difluoro-4-biphenylyl)-2-methylmalonate was hydrolysed and the resulting crude 2-(2,4'-difluoro-4-biphenylyl)-2-methylmalonic acid was decarboxylated to give 2-(2,4'-difluoro-4-biphenylyl)-propionic acid, m.p. 118°-119°C.

Sources & evidence

ORD record
ord-552e608cac3d4deb9012ed8a08624183
Source dataset
uspto-grants-1976_01
Patent number
US03932499

Reaction notes

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