Methanol → HCID 21566289, compound

HRID 1580290Notes

Reaction equation

HRID 1580290 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1.S(=O)(=O)(O)O.[CH3:25]O>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([O:18][CH3:25])=[O:17])=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 21566267HCID 21566267, compound

Product 1

HCID 21566289HCID 21566289, compound

Procedure

2-(2',4'-Difluoro-4-biphenylyl)propionic acid (2 g.), methanol (20 ml.) and concentrated sulphuric acid (0.6 ml.) were refluxed for 16 hours. Excess methanol was distilled in vacuo, the residue was diluted with water and the oil isolated in ether. Distillation gave methyl 2-(2',4'-difluoro-4-biphenylyl)propionate, b.p. 118°-120°C./0.2 mm.

Workup

  1. distillationExcess methanol was distilled in vacuo
  2. additionthe residue was diluted with water
  3. customthe oil isolated in ether
  4. distillationDistillation

Sources & evidence

ORD record
ord-db739b68fcdd41e0b23d927ee12cfb4c
Source dataset
uspto-grants-1976_01
Patent number
US03932499

Reaction notes

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