Ethanol → HCID 21566284, compound

HRID 1580292Notes

Reaction equation

HRID 1580292 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1.S(=O)(=O)(O)O.[CH2:25](O)[CH3:26]>>[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([O:11][CH2:25][CH3:26])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 21566291HCID 21566291, compound

Product 1

HCID 21566284HCID 21566284, compound

Procedure

2-(2,4'-Difluoro-4-biphenylyl)propionic acid (830 mg.), ethanol (10 ml.) and concentrated sulphuric acid (0.5 ml.) were refluxed for 16 hours. The solution was diluted with ice-water (200 ml.) and extracted with ether. After the usual washing, evaporation of the ether and distillation of the residue gave ethyl 2-(2,4'-difluoro-4-biphenylyl)-propionate, b.p. 145°-146°C./0.8 mm.

Workup

  1. extractionextracted with ether
  2. customAfter the usual washing, evaporation of the ether and distillation of the residue

Sources & evidence

ORD record
ord-44663ac7d53a494d93731d6d4285693f
Source dataset
uspto-grants-1976_01
Patent number
US03932499

Reaction notes

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