Acetic Anhydride → HCID 20361754, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 12.8 g. of 2[(2-pyridyl)hydroxybenzyl] imidazoline in 25 ml. of dioxane and, with vigorous stirring, slowly add 2.4 ml. of acetic anhydride in a drop-wise fashion. After each 0.5 ml. addition warm the solution to 60° C for 5 min. and then cool the solution to 20° C before adding additional anhydride. Continue the stirring for 20 hours, filter the precipitated acetate salt and concentrate the resulting filtrate to about 10 mls. Recrystallize the desired product from alcohol to yield 1-acetyl-2[(2-pyridyl)-hydroxybenzyl]imidazoline, m.p. 150°-153° C.

Provenance & Evidence