Water → N'-(4-chlorocyclohexyl)-urea

Participants

Reaction Steps

7.8 g of N-[4-(β-acetoamido-ethyl)-benzenesulfonyl]-N'-(4-chlorocyclohexyl)-urea (melting point 151° -153°C) are heated under reflux for 2 hours with 1.6 g of sodium hydroxide and 30 ml of water. Then the whole is cooled to room temperature, 20 ml of acetone are added and 1.2 g of glacial acetic -chlorobenzamido>-ethyl)-benzenesulfonyl] acid, and 4.1 g of 2-methoxy-5-chlorobenzoylchloride are added in portions and stirring is continued for 1 hour. The precipitate if filtered off with suction, stirred with bicarbonate solution and recrystallized from methanol/dimethylformamide. The N-[4-(β-<-methoxy-5-chlorobenzamido>-ethyl)-benzenesulfonyl]-N'-(4-chlorocyclohexyl)-urea obtained melts at 178°-179°C.

Provenance & Evidence