Water → HCID 131709911, compound

Participants

Reaction Steps

9.6 g of 4-(β-<2-methoxy-5-chlorobenzamido>α-methylethyl)-benzenesulfonamide are dissolved in 250 ml of dioxane. 6.9 g of finely ground potassium carbonate are added and the whole is heated to boil for 2 hours while stirring. 4.5 g of 4.4-diethylcyclohexyl-isocyanate are added dropwise while continuing to stir. Stirring and heating is continued for 8 hours, the whole is poured into water and acidified. The crystalline precipitate obtained is filtered off with suction and dried. The whole is dissolved in dimethylformamide, methanol is added and thus a crystalline mass is obtained of N-[4-(β-<2-methoxy-5-chlorobenzamido>α-methyl)-ethyl-benzenesulfonyl]-N'-(4.4-diethyl-cyclohexyl)-urea melting at 161°-163°C.

Provenance & Evidence