Formaldehyde → HCID 15581944, compound

HRID 1580442Notes

Reaction equation

HRID 1580442 reaction equation
[CH3:1][CH:2]([CH3:13])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([NH2:6])=[S:5].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[CH2:20]=O>CO>[CH3:1][CH:2]([CH3:13])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([NH:6][CH2:20][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[S:5]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 15581943α-(1-Methylethyl)-2-pyridineethanethioamide

Product 1

HCID 15581944HCID 15581944, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 1.0 g. of 3-methyl-2-(2-pyridyl)-thiobutanamide in 20 ml. of methanol is added, at one time, 0.45 g. of morpholine and 0.42 ml. of a 37% formalin solution. The reaction is stirred for 15 hours at 25°C., then refluxed on a steam bath for 20 minutes. The solvents are evaporated in vacuo and the residue is distilled to give 3-methyl-N-morpholinomethyl-2-(2-pyridyl)thiobutanamide, b.p. 110°-112°C. (0.005 mm.).

Workup

  1. temperaturerefluxed on a steam bath for 20 minutes
  2. customThe solvents are evaporated in vacuo
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-fc091a423b474df68ee6729908eecea0
Source dataset
uspto-grants-1976_01
Patent number
US03932641

Reaction notes

Loading…