HCID 46888274, compound → HCID 71322013, compound

HRID 1580470Notes

Reaction equation

HRID 1580470 reaction equation
[CH2:1]([O:3][C:4]([C:6]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC)=O)=C(C)[NH:10][C:11]=1[CH2:12][CH3:13])=[O:5])[CH3:2]>C(O)C>[CH2:1]([O:3][C:4](=[O:5])[CH:6]=[C:11]([CH2:12][CH3:13])[NH2:10])[CH3:2]

Participants

3

Reactant 1

HCID 46888274HCID 46888274, compound

Product 1

HCID 71322013HCID 71322013, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After 8 hours' boiling of a solution of 12.5 g 3'-nitrobenzylidene-acetoacetic acid methyl ester and 7.2 g β-ethyl-β-aminoacrylic acid ethyl ester in 70 ml ethanol, 2-methyl-6-ethyl-4-(3'-nitrophenyl) 1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-ethyl ester of melting point 123°C (acetic ester/petroleum) was obtained. Yield 71% of theory.

Sources & evidence

ORD record
ord-4113dd4314d2450e8d70f9936635161d
Source dataset
uspto-grants-1976_01
Patent number
US03932645

Reaction notes

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