Potassium Nitrate → 1-(3-Chloro-4-hydroxy-5-nitrophenyl)-ethanone

HRID 1580527Notes

Reaction equation

HRID 1580527 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([N+:12]([O-:14])=[O:13])[C:7]=1[OH:8]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 10515141-(3-Chloro-4-hydroxyphenyl)ethanone

Product 1

HCID 215618781-(3-Chloro-4-hydroxy-5-nitrophenyl)-ethanone

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A 500-milliliter flask was charged with 300 milliliters of concentrated sulfuric acid, chilled to 5° to 10° C. and at this temperature 17.1 grams of 3'-chloro-4'-hydroxyacetophenone was slowly added. To the stirred clear solution 20 grams of potassium nitrate was slowly added during a period of about 30-40 minutes while the temperature was maintained between 5° and 10° C. After stirring for an additional 45-60 minutes, the solution was stirred into 1,000 grams of ice. The resulting pale yellow solid was filtered and washed with water.

Workup

  1. additionwas slowly added
  2. temperaturewas maintained between 5° and 10° C
  3. filtrationThe resulting pale yellow solid was filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-24001ad007c046d19c1c2e0242ab2883
Source dataset
uspto-grants-1976_01
Patent number
US03933472

Reaction notes

Loading…