HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2,2,3',5'-Tetrachloro-4'-hydroxypropiophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 1-(3,5-Dichloro-4-hydroxyphenyl)ethanone | HCID 86920 | — |
| Product | 2,2,3',5'-Tetrachloro-4'-hydroxypropiophenone | HCID 21561893 | — |
Reaction Steps
A 500-milliliter reaction flask was charged with 21.9 grams (0.1 mole) of the 3',5'-dichloro-4'-hydroxyacetophenone, 250 grams of chloroform, and 10 grams of ethanol. The compound was chlorinated with 17.8 grams (0.25 mole) of chlorine gas added at 50°-55° C. over a period of 2.5 hours. The solution was evaporated under reduced pressure, and 27.1 grams of crude, white 2,2,3',5'-tetrachloro-4'-hydroxpropiophenone was obtained. Analysis calcd.: Hydrolyzable Cl, 24.6. Found: Hydrolyzable Cl, 22.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03933472 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-ccb4a4d5a3934b14ad2383ea4d46aed0 |
| Source note | uspto-grants-1976_01 |