Formaldehyde → HCID 21563032, compound

Participants

Reaction Steps

To a solution of 1.8 g. (0.0091 mole) of 2-dimethylamino-2-(2-pyridyl)thioacetamide in 25 ml. of methanol is added 0.9 g. (0.0015 mole) of morpholine in 2 ml. of methanol and 0.9 g. (0.0015 mole) of 37% aqueous formaldehyde solution in 2 ml. of methanol. The resulting solution is stirred at room temperature for 18 hours. The solvent is removed under reduced pressure and ether is added to the residue. The mixture is cooled at -20°C. for 4 hours and then filtered. The solvent is evaporated from the filtrate to give 2-dimethylamino-N-morpholinomethyl-2-(2-pyridyl)-thioacetamide.

Provenance & Evidence