Hydrochloric Acid → HCID 68131133, compound

Participants

Reaction Steps

A solution of 11β-chloro-21-hydroxy-16β-methyl-17-propionyloxypregna-1,4-diene-3,20-dione(75 mg) in pyridine (1 ml) was cooled to 0° and treated with stirring with propionyl chloride (0.04 ml). After 90 minutes a little water was added and the solution poured into dilute hydrochloric acid. The precipitated solid was removed by filtration and recrystallized from methanol to give the title compound, m.p. 220°-222° (K), [α]D + 105° (c 0.6, chloroform) λmax 240nm (ε 15,060) (Found C, 65.9; H, 7.2; Cl, 6.7. C28H37ClO6 requires C, 65.7; H, 7.55; Cl, 7.0%).

Provenance & Evidence