Water → HCID 68132151, compound

Participants

Reaction Steps

A solution of 17-acetoxy-11β-chloro-21-hydroxy-16β-methylpregna-1,4-diene-3,20-dione (67 mg.) in pyridine (1 ml.) at 0° was treated with propionyl chloride (0.03 ml.). After one hour, a little water was added and the solution was diluted with dilute hydrochloric acid. The precipitated solid was collected and recrystallized from methanol to give the title compound, m.p. 213°-215° (K), [α]D + 108.4° (c 0.6, chloroform) λmax 240 nm (ε 15,760) (Found: C, 65.9; H, 7.2. C27H35Cl O6 requires C, 66.0; H, 7.2).

Provenance & Evidence