Ammonia → 3-Amino-1-phenoxy-3-methylbutan-2-one oxime hydrochloride

Participants

Reaction Steps

A suspension of 2-chloro-4-(p-methoxy)phenoxy-2-methyl-3-nitrosobutane (V) (4.0 g) in methanol (approx. 80 ml) was refluxed while ammonia gas was bubbled through the suspension. Methanol was added occasionally to keep the volume of the solution approximately constant. After 6 hours the solution was evaporated and the residue, after washings with acetone, gave the ketoxime hydrochloride (IV) (3.2 g, yield 75%) as colourless crystals, m.p. 225°.

Provenance & Evidence