Sodium Methoxide → HCID 4961624, compound

HRID 1580636Notes

Reaction equation

HRID 1580636 reaction equation
[Br-].[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N+:4]=1[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C[O-].[Na+]>CO>[C:10]1([CH2:9][N:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]2=[NH:2])[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 12255191HCID 12255191, compound

Product 1

HCID 4961624HCID 4961624, compoundYield 96.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-amino-1-(phenylmethyl)pyridinium bromide (94.5 g) in 700 ml of methanol is added, portionwise, a total of 38.5 g of sodium methoxide. The mixture is stirred and heated under reflux conditions for 2.5 hours. Workup yields 63.4 g of the title compound, melting point 52°-54°C.

Workup

  1. temperatureheated under reflux conditions for 2.5 hours

Sources & evidence

ORD record
ord-05cddba18ef04aaa81610aead1167f91
Source dataset
uspto-grants-1976_01
Patent number
US03933836

Reaction notes

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