Acetic Anhydride → HCID 53797125, compound

HRID 1580639Notes

Reaction equation

HRID 1580639 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:6]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>N1C=CC=CC=1>[C:20]([NH:1][C:2]1[S:3][C:4]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[N:6]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13027306HCID 13027306, compound

Product 1

HCID 53797125HCID 53797125, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 13.4 grams of ethyl (2amino-4-p-chlorophenyl-thiazol-5-yl)acetate and 10.2 grams of acetic anhydride in 50 c.c. of anhydrous pyridine is refluxed for 1/2 an hour. The solution is poured on ice. The precipitated solid is filtered off, washed several times with H2O, and recrystallised from 80% alcohol, m.p. 187°-88°C.

Workup

  1. additionThe solution is poured on ice
  2. filtrationThe precipitated solid is filtered off
  3. washwashed several times with H2O
  4. customrecrystallised from 80% alcohol, m.p. 187°-88°C.

Sources & evidence

ORD record
ord-81c989dc40d54ac9b021e81e6c9c26f9
Source dataset
uspto-grants-1976_01
Patent number
US03933838

Reaction notes

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