Phenyl isocyanate → HCID 53996546, compound

HRID 1580640Notes

Reaction equation

HRID 1580640 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[S:12][C:13]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[N:15]=1>CCOCC>[C:1]1([NH:7][C:8]([NH:10][C:11]2[S:12][C:13]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:14]([C:16]3[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=3)[N:15]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 13027306HCID 13027306, compound

Product 1

HCID 53996546HCID 53996546, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2 Grams of phenylisocyanate in 50 c.c. ether are added to a suspension of 5 g. of ethyl (2-amino-4-p-chlorophenyl-thiazol-5-yl)-acetate in 200 c.c. of anhydrous ether. After 24 hours the precipitated solid is filtered off, m.p. 192°-93°C.

Workup

  1. filtrationAfter 24 hours the precipitated solid is filtered off

Sources & evidence

ORD record
ord-b10bc68dd072408fb1de1ad69566d291
Source dataset
uspto-grants-1976_01
Patent number
US03933838

Reaction notes

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