反应详情

7.8 Grams of 4-(7-Chloro-4-quinolylamino)-benzenesulphonyl chloride hydrochloride [prepared as in Example 1(b)] were added in portions to a stirred ice-cooled mixture of 3.63 grams of 4-amino-1-cyclohexyl-piperidine and 21.2 grams of sodium carbonate in 60 milliliters of water and 50 milliliters of chloroform. After stirring overnight at room temperature the chloroform layer was separated, washed with water, dried and evaporated to give a brown solid. This was triturated with hexane, the resultant solid dissolved in chloroform and diiso-propyl ether added to precipitate a solid which was triturated with hexane to give 1.9 grams of the title compound as the hemihydrate. Melting point 192°-193°C.

1. temperaturecooled
2. customwas separated
3. washwashed with water
4. customdried
5. customevaporated
6. customto give a brown solid
7. customThis was triturated with hexane
8. dissolutionthe resultant solid dissolved in chloroform
9. additiondiiso-propyl ether added
10. customto precipitate a solid which
11. customwas triturated with hexane