3-amino-N-ethylpiperidine → 3-(7-chloro-4-quinolylamino)-N-(1-ethyl-3-piperidyl)benzenesulphonamide

HRID 1580688Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:14]=[C:15]([S:19]([OH:22])(=O)=[O:20])[CH:16]=[CH:17][CH:18]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.Cl.S(Cl)(Cl)(=O)=O.[NH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][N:32]([CH2:36][CH3:37])[CH2:31]1>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:14]=[C:15]([S:19]([NH:29][CH:30]4[CH2:35][CH2:34][CH2:33][N:32]([CH2:36][CH3:37])[CH2:31]4)(=[O:20])=[O:22])[CH:16]=[CH:17][CH:18]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 980943-amino-N-ethylpiperidine

HCID 19012189Sulphonylchloride hydrochloride

HCID 215635433-(7-Chloro-4-quinolylamino)benzenesulphonic acid

Product 1

HCID 215635463-(7-chloro-4-quinolylamino)-N-(1-ethyl-3-piperidyl)benzenesulphonamide

Procedure

3-(7-Chloro-4-quinolylamino)benzenesulphonic acid was converted to the corresponding sulphonylchloride hydrochloride and reacted with 3-amino-1-ethylpiperidine in a similar manner to that described in Example 1 (b) to give the title compound.

Sources & evidence

ORD record: ord-61fe2cba52524db9906f75411af44638
Source dataset: uspto-grants-1976_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03933829

Reaction notes

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