Ammonia → HCID 21392592, compound

HRID 1580707Notes

Reaction equation

HRID 1580707 reaction equation
[OH:1][CH:2]([CH3:21])[CH2:3][O:4][C:5]1[C:10]2[C:11](=[O:20])[CH:12]=[C:13]([C:15](OCC)=[O:16])[O:14][C:9]=2[CH:8]=[CH:7][CH:6]=1.[NH3:22]>>[OH:1][CH:2]([CH3:21])[CH2:3][O:4][C:5]1[C:10]2[C:11](=[O:20])[CH:12]=[C:13]([C:15]([NH2:22])=[O:16])[O:14][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86732991HCID 86732991, compound

Product 1

HCID 21392592HCID 21392592, compound

Procedure

By the method of Example 1 (c) 32 parts of 5-(2-hydroxypropoxy)-4-oxo-4H-1-benzopyran-2-carboxylic acid, ethyl ester were treated with ethanolic ammonia to give 23.3 parts of 5-(2-hydroxypropoxy)-4-oxo-4H-1-benzopyran-2-carboxamide, which crystallised from a mixture of ethanol and chloroform as a white solid, melting point 229°-231°C.

Sources & evidence

ORD record
ord-0c278491ef6d4b7d9e3c3622109d8424
Source dataset
uspto-grants-1976_01
Patent number
US03933845

Reaction notes

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