HCID 178446915, compound → HCID 178446909, compound

Participants

Reaction Steps

To a solution of 1 part of 5-[5-(3-methyl-n-butoxy)-4-oxo-4H-1-benzopyran-2-yl]tetrazole in 50 parts of ethanol was added 5 parts of Raney nickel catalyst. The resulting mixture was hydrogenated at 20°C and 45 lbs/sq. in. pressure for 8 hours. The catalyst was filtered off and the filtrate was evaporated to give an oil which solidified on trituration with petroleum ether (b.p. 40°-60°C). This solid was crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 40°-60°C) to give 0.2 parts of 5-[2,3-dihydro-5-(3-methylbutoxy)-4-oxo-4H-1-benzopyran-2-yl]tetrazole as a white solid, m.p. 134°-137°C. The structure of this product was confirmed by n.m.r. and m.s. measurements.

Provenance & Evidence