1-Chloro-2-iodobenzene → 1-(2-Chlorophenyl)-3-(2-hydroxyiminopropyl)indole

Participants

Reaction Steps

2.1 G (0.03 mole) of hydroxylamine hydrochloride and 2.1 g of sodium acetate are added, all at once, to 5.8 g (0.02 mole) of 1-(2-chlorophenyl)-3-(2-oxopropyl)indole prepared as described in example 1 but using 2-chloroiodobenzene instead of iodobenzene are dissolved in 50 ml of ethanol. The mixture is stirred overnight. The oxime formed is then filtered, washed in water and recrystallised, after drying, from 30 ml of di-isopropyl ether. Product = 4.3 g: Melting point (k) = 127°. Yield = 71%.

Provenance & Evidence