Sulfuric Acid → HCID 718193, compound

HRID 1580767Notes

Reaction equation

HRID 1580767 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[O:13][CH3:14])(=[O:3])[CH3:2].S(=O)(=O)(O)O.[Br:20]Br>O>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([Br:20])=[CH:7][C:6]=1[O:13][CH3:14])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 24408BromineHCID 77015Acetamide, N-(2,5-dimethoxyphenyl)-

Product 1

HCID 718193HCID 718193, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

300 Parts of 1-acetylamino-2,5-dimethoxybenzene were introduced at about 5°C in 1500 parts of 95 % sulfuric acid while stirring, 127 Parts of bromine were added dropwise at about 5°C with outside cooling. The mixture was stirred at 20°C for about 3 hours, 6000 parts by volume of water were added dropwise (a temperature of 25°C is not to be exceeded), the precipitate was suction-filtered and dried. 381 parts of 1-acetylamino-2,5-dimethoxy-4-bromobenzene (=90.4 % of the theory) were obtained.

Workup

  1. stirringThe mixture was stirred at 20°C for about 3 hours
  2. filtrationwas suction-filtered
  3. customdried

Sources & evidence

ORD record
ord-678b57731de948c0b82aa471c65c54f9
Source dataset
uspto-grants-1976_01
Patent number
US03933887

Reaction notes

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