Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Thioglycolate → 4,5-Diphenyl-2-oxazolyl mercaptoacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Thioglycolate | HCID 12185 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-4,5-diphenyloxazole | HCID 13131162 | — |
| 반응물 | 2-Bromo-4,5-diphenyl-oxazole | HCID 21408706 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4,5-Diphenyl-2-oxazolyl mercaptoacetic acid | HCID 21408360 | — |
반응 단계
12 g. of thioglycolic acid ethyl ester is added to a suspension of 2.4 g. of NaH in 200 ml. of freshly distilled DMF, and the mixture is agitated until the evolution of hydrogen has ceased. Thereafter, 25.5 g. of 2-chloro-4,5-diphenyl-oxazole or 30 g. of 2-bromo-4,5-diphenyl-oxazole is added to the mixture. The latter is agitated for 5 hours at 80° and worked up as usual, thus obtaining the ethyl ester of 4,5-diphenyl-2-oxazolyl-mercaptoacetic acid, b.p. 207°-210°/0.1 mm.; m.p. 54°-56° (hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03933840 |
| 출처 데이터셋 | uspto-grants-1976_01 |
| ORD ID | ord-77c0f9ec793b4057b66445804ac4916a |
| 출처 메모 | uspto-grants-1976_01 |